radiation and cadmium induced biochemical alterations in mouse kidney

Authors

r.k. purohit radiation biology laboratory, department of zoology, govt. dungar college, bikaner, india

a. chakrawarti radiation biology laboratory, department of zoology, govt. dungar college, bikaner, india

k.m. bhartiya radiation biology laboratory, department of zoology, govt. dungar college, bikaner, india

abstract

background: in the present investigation radiation and cadmium induced biochemical changes in the kidney of swiss albino mice have been studied. materials and methods: for this purpose, adult male swiss albino mice (6-8 weeks old) were divided into four groups. group i (sham-irradiated), group ii (treated with cdcl2 solution 20 ppm), group iii (irradiated with 1.25, 2.5 and 5.0 gy gamma rays), group iv (both irradiated with 1.25, 2.5 and 5.0 gy gamma rays and treated with cdcl2 solution). the animals were autopsied after 1, 2, 4, 7, 14 and 28 days of treatment. the kidney was taken out and different biochemical parameters, such as total proteins, glycogen, cholesterol, acid phosphatase activity, alkaline phosphatase activity, dna and rna were estimated. results: in irradiated animals, the values of total proteins, glycogen, acid phosphatase, alkaline phosphatase activity and rna increased continuously up to day-7 and decreased thereafter up to day-28. the changes were dose dependent. in cdcl2 treated animals, the values of glycogen and total proteins decreased during the early intervals and increased thereafter whereas the values of acid and alkaline phosphatase activity and rna increased during early intervals and decreased thereafter. the values of cholesterol and dna showed decrease in all the experimental groups (except group i) up to day-7 and increase thereafter up to day-28. after combined treatment also, the parameters followed the same pattern of increase and decrease, but the changes were more pronounced indicating their synergistic effect. the biochemical parameters showed highly significant values (p<0.001) as compared to normal ones. conclusion: these results indicate that combined treatment of cadmium and gamma radiations causes synergistic or additive effect.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Radiation and cadmium induced biochemical alterations in mouse kidney

Background: In the present investigation radiation and cadmium induced biochemical changes in the kidney of Swiss albino mice have been studied. Materials and Methods: For this purpose, adult male Swiss albino mice (6-8 weeks old) were divided into four groups. Group I (sham-irradiated), Group II (treated with CdCl2 solution 20 ppm), Group III (irradiated with 1.25, 2.5 and 5.0 Gy gamma rays), ...

full text

Radiation and cadmium induced biochemical alterations in mouse kidney

The extensive use of atomic radiations now-a-days in various branches of natural economy, biology, physiology, medicine, science and technology has made radiation injury an urgent problem attracting the attention not only of specialists in a variety of clinical disciplines but also of a vast army of theoretical scientists. The wide variety of tissues constituting the kidney together with its im...

full text

Modulation of radiation and cadmium induced biochemical changes in mouse kidney by Emblica officinalis Linn

Background: Protective effect of Emblica against radiation and cadmium induced biochemical changes in mouse kidney has been studied. Materials and Methods: Adult male mice were divided into seven groups: I (shamirradiated), II (cadmium chloride), III (irradiated with 2 Gy gamma rays), IV (radiation and cadmium chloride), V (Cadmium chloride and Emblica), VI (radiation and Emblica), VII...

full text

modulation of radiation and cadmium induced biochemical changes in mouse kidney by emblica officinalis linn

background: protective effect of emblica against radiation and cadmium induced biochemical changes in mouse kidney has been studied. materials and methods: adult male mice were divided into seven groups: i (shamirradiated), ii (cadmium chloride), iii (irradiated with 2 gy gamma rays), iv (radiation and cadmium chloride), v (cadmium chloride and emblica), vi (radiation and emblica), vii (radiati...

full text

Post-treatment effects of Alstonia scholaris extract against radiation-induced biochemical alterations in Swiss albino mice

Background: This study has been undertaken to find out the possible radioprotective potential of the Alstonia scholaris extract (ASE). Materials and Methods: For experimental study, healthy Swiss albino male mice were selected from an inbred colony and divided in four groups. Group I (normal) did not receive any treatment. Group II was orally supplemented ASE once daily at the dose of ...

full text

Protective effect of alpha-tocopheral on biochemical and histological alterations induced by cadmium in rat testes.

Cadmium (Cd) is a potential environmental pollutant and causes severe damage to reproductive organs in adults including ovary and testes. Of all antioxidants alpha-tocopheral is considered to be most potent chain breaking antioxidant. Our aim was to study the effect of alpha-tocopheral on biochemical and histological alterations induced by Cd in testes of rats. Group 1 served as control, while ...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of radiation research

جلد ۵، شماره ۳، صفحات ۱۲۵-۱۳۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023